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10-nights voyage on the Crystal Serenity |  Sailing from Cartagena to Fort Laudrdale on Crystal Cruises

Mon, Feb 29 - Fri, March 10, 2028

Cartagena to Fort Lauderdale

Sailing from Cartagena to Fort Lauderdale is a vibrant journey through the heart of Central America and the Western Caribbean, blending colorful cultures, tropical landscapes, and unforgettable coastal cities. After departing Cartagena’s historic walled old town, your voyage calls on Colon, gateway to the Panama Canal, followed by lush Puerto Limón, where rainforest adventures and rich Afro-Caribbean heritage await. Next comes Roatán, famous for crystal-clear waters and vibrant coral reefs—perfect for snorkeling, beach time, or simply soaking in island life.

The itinerary continues with a stop in Santo Tomás de Castilla, offering access to Guatemala’s cultural treasures, before heading to Belize City for Mayan ruins, cave tubing, or barrier-reef excursions. Your final port, Cozumel, delivers classic Caribbean beauty with turquoise seas, vibrant shopping, and world-class diving. It’s a perfectly balanced sailing—rich history, exotic nature, and laid-back beach vibes—all leading to a smooth arrival in Fort Lauderdale, making this route an ideal escape for travelers craving both adventure and relaxation in one unforgettable cruise.

Itinerary details, including arrival/departure times and days of port calls, are subject to change. Prices are per person, cruise only, based on double occupancy, specified stateroom category, in USD and are subject to availability. Governmental departure taxes and fees are additional. Prices and promotions are for new individual bookings, are subject to availability, may change without notice, are capacity-controlled, and may be changed or withdrawn at any time. Ask your Travel Advisor for the most up to date pricing and promotions.

Set sail from $5,300 per person includes the destination fee

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Cruise Itinerary


  • Day 1

    Cartagena

  • Day 2

    Cartagena

  • Day 3

    Colon

  • Day 4

    Puerto Limon

  • Day 5

    Sailing

  • Day 6

    Roatan

  • Day 7

    Santo Tomas

  • Day 8

    Belize City

  • Day 9

    Cozumel

  • Day 10

    Sailing

  • Day 11

    Fort Lauderdale

Itinerary details, including arrival/departure times and days of port calls, are subject to change.